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(0:00) Jason and Sacks welcome Microsoft CEO Satya Nadella (1:31) Future of AI copilots and agents, impact on white collar work (8:01) How Microsoft has scaled revenue and profits with flat headcount...
Podcast episode
32:00
January 21st, 2026
(0:00) Bestie intros! (4:18) Iran's breaking point: regime change coming? (14:28) Solving energy prices: Microsoft first hyperscaler to "pay its own way" and subsidize residential electric costs (31:18) OpenAI's compute deal with...
Podcast episode
1:10:45
January 17th, 2026
(0:00) Friedberg intros FDA Commissioner Marty Makary (3:21) Inside the 42 major FDA reforms in 10 months (7:51) The China Race: Winning back biotech leadership (13:14) Accelerating drug approvals safely, how to...
Podcast episode
1:29:48
January 15th, 2026
Artificial intelligence has arrived in the legal profession. In this special episode, Kyle and Katya examine AI's growing role in the world of law from criminal defense to M&A and much in...
Podcast episode
21:33
January 14th, 2026
(0:00) David Friedberg introduces Adam Carolla! (1:32) Palisades Fire one year out: the rebuilding crisis in LA (7:39) Gyno-fascism and safety culture (15:49) Media bias and gender dynamics (28:51) DEI, Hollywood's transformation...
Podcast episode
1:09:49
January 13th, 2026
(0:00) California exodus, asset seizure tax, Besties to Austin? (12:27) Biggest Political Winner (17:45) Biggest Political Loser (32:15) Biggest Business Winner (40:51) Biggest Business Loser (49:34) Biggest Business Deal (56:15) Most Contrarian...
Podcast episode
1:31:11
January 10th, 2026
(0:00) Commerce Secretary Howard Lutnick tells a hilarious Air Force One story (2:24) Chamath intros Secretary Lutnick (7:28) Full scope of the Commerce Department (12:59) How Trump's tariff agenda was planned and...
Podcast episode
1:27:20
January 9th, 2026
(0:00) Guest intros: Jasons introduces Bob Sternfels (McKinsey) and Hemant Taneja (General Catalyst) (2:52) The pace of innovation and why VC's are buying hospitals (9:30) CFOs vs CIOs and unlocking growth (20:46...
Podcast episode
51:22
January 8th, 2026
Michael Kohagen structures mergers and acquisitions for clients across the deal spectrum, from family businesses selling for $5 million to headline-grabbing deals. He explains how smaller deals offer closer client relationships—often working...
Podcast episode
31:36
January 7th, 2026
(0:00) Bestie intros! Nick Shirley joins the show to discuss his recent investigation on potential daycare fraud in Minnesota (3:32) Nick's background, how he got into investigative reporting and YouTube, independence, finding...
Podcast episode
1:43:22
December 31st, 2025
(0:00) Intro! (2:47) Tony Hinchcliffe roasts the Besties (15:01) Interview: Kill Tony success, MSG rally, origin story, free speech in Europe (36:03) The Besties play Kill Tony! (50:14) The 2025 Bestie Awards...
Podcast episode
1:18:19
December 24th, 2025
(0:00) Treasury Secretary Scott Bessent joins the show (0:55) Recapping 2025 and the state of the economy (3:13) Tariffs: Leverage, legal challenges, implementation (15:20) Affordability: inflation, BLS data, interest rates (23:00) The...
Podcast episode
56:58
December 22nd, 2025
(0:00) Bestie intros! (0:19) Bernie Sanders calls for AI datacenter moratorium, how to solve the negative perception of AI (17:15) Anti-AI astroturfing: Is the AI sentiment manufactured by special interests? (32:39) Economy...
Podcast episode
1:30:27
December 19th, 2025
Duncan Kemp, a state government lawyer, took an unconventional path to environmental law. After working in college athletics fundraising and earning an MFA in Creative Writing, he entered law school part-time with...
Podcast episode
30:03
December 17th, 2025
(0:00) Tucker joins the besties! (4:11) Paramount vs Netflix: bidding war over Warner Bros Discovery (25:40) What's behind the rise of Nick Fuentes and America First? (49:13) Understanding the Anti-AI sentiment (1:21:52...
Podcast episode
1:38:31
December 13th, 2025
Molly Henry represents international ship owners in a practice spanning oil spill response, vessel arrests, cargo disputes, and casualties at sea. She explains how admiralty law—a conglomeration of international treaties and federal...
Podcast episode
35:54
December 10th, 2025
(0:00) Bestie intros (0:12) OpenAI declares "Code Red" as competitors eat away ChatGPT market share (28:14) David Sacks vs. New York Times (51:24) New poverty line, America's slow descent into socialism Follow...
Podcast episode
1:14:17
December 6th, 2025
Mia Getlin specializes in the state-legal cannabis industry in Oregon and Washington. She shares insights into the challenges and complexities of navigating the highly-regulated cannabis sector, emphasizing the importance of trust-building with...
Podcast episode
32:55
December 3rd, 2025
(0:00) Molly Bloom joins the besties live in Las Vegas! (1:48) Did Jason actually play in "Molly's Game"? (3:23) Molly's background, starting the game, getting strong-armed by a famous actor, getting stiffed...
Podcast episode
38:26
November 26th, 2025
(0:00) Bestie intros LIVE from The Venetian Las Vegas (1:13) Epstein Files breakdown (10:06) Biggest Epstein questions: where did his money come from? (14:44) Tether's booming business (23:50) Michael Burry vs. Friedberg...
Podcast episode
1:01:53
November 22nd, 2025

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